Drug Discovery & Characterization

The Complexity of Modern Biologics Requires Thoughtful Design

01
Structural Integrity

- Complex molecules (mAbs, BsAbs, fusion proteins) often suffer from poor structural stability.
- This results in low expression yields and poor shelf-life.
02
Functional Complexity

- Requires testing of multi-target affinity, internalization, and functional engagement.
- Specialized systems (e.g., bioassay cell lines) are needed.
03
In Vivo Behavior

- Risk of poor PK/PD or high immunogenicity can compromise development.
- Requires early-stage modeling.
04
Optimization Requirements

- Needs improvement in affinity, Fc function, or humanization.
- Sequence-level changes can drastically alter manufacturability.

Innovative biologics face many development challenges.
At HiLand, we bring clarity by aligning risk factors with targeted solutions.

Technical Platforms to Address Drug Development Risks

Six validated platforms to assess, optimize, and advance your therapeutic candidates.

Workflow

01

Sequence Evaluation
02

Structure & Simulation
03

Stability Assessment
04

Risk Investigation
05

Mitigation Strategy

Related Services

Services to further support candidate readiness and downstream success:

In silico prediction

By using in silico analytical tools and powered by AI technologies, features of bio-molecules are subject to evaluation of potential structural caveats

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