Models of Digestive Diseases
Our gastrointestinal and hepatobiliary model platform enables robust efficacy and MoA testing across IBD, ulcer/gastritis, liver and pancreatic diseases, and GI oncology. We offer DSS/TNBS colitis for ulcerative/Crohn's disease, H. pylori and ulcer models, NASH/NAFLD and liver fibrosis (MCD/CDAA diets, CCl₄), cerulein-induced pancreatitis, and AOM/DSS colorectal cancer. With clinically relevant endpoints—endoscopy and histology scoring, cytokines, microbiome readouts, liver enzymes and fibrosis indices—we generate decision-ready data to de-risk small molecules, biologics, and microbiome-based therapies.
List of Diseases and Research Models
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Disease Type
Animal Model / Study
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Gastric Ulcer
•Model of Aspirin-induced gastric ulcer
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Gastric Mucosal Injury
•Model of pyloric ligation-induced gastric ulcer
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Gastric Acid Secretion
•Model of histamine-induced gastric ulcer
•Model of restraint water-immersion stress-induced gastric ulcer
•Model of anhydrous ethanol-induced gastric mucosal injury
•Model of glacial acetic acid-induced gastric ulcer
•Isolated gastric acid secretion and other tests -
Duodenal Ulcer
•Model of cysteine-induced duodenal ulcer
•Model of glacial acetic acid-induced duodenal ulcer -
Gastrointestinal Motility Disorder
•Gastric emptying test
•Intestine propulsion test
•Model of folium sennae-induced diarrhea
•Model of diphenoxylate/loperamide-induced constipation -
Liver Disease
•Hepatitis
