Nervous System Disease Models
We develop animal models to investigate neurological disorders involving cognition, learning, memory, and motor function. Neurobehavioral assessments support drug discovery for conditions like Alzheimer's, Parkinson's, epilepsy, and neurodevelopmental diseases.
List of Diseases and Research Models
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Disease Type
Animal Model / Study
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Pain
•Formaldehyde-induced pain model
•Model of kaolin plus carrageenan-induced toe pain after inflammation
•Model of glacial acetic acid-induced writhing pain
•Electrical stimulation/hot plate method/tail-flick method/cold stimulation tests -
Dementia
•Model of Aβ25-35 plus D-galactose-induced Alzheimer's disease
•Model of bilateral common carotid arteries occlusion-induced vascular dementia -
Stroke
•Bilateral common carotid arteries occlusion model
•Model of thread embolism-induced middle cerebral artery occulation -
Insomnia
•Model of PCPA-induced insomnia
•Model of tail pinch plus PCPA-induced liver depression type insomnia
•Model of picrotoxin injection in locus coeruleus-induced insomnia -
Convulsion
•Pentetrazol-induced convulsion model
•Picrotoxin-induced convulsion model
•Febrile convulsion model -
Depression
•Model of forced swimming or tail suspension-induced acute stress depression
•Model of electric shock shuttle box-induced depression
•5-hydroxy tryptamine enhancement model
