Endocrine and Metabolic Disease Models
Animal models are vital for studying endocrine and metabolic disorders such as hyperlipidemia, osteoporosis, and hyperuricemia. These models support the development of treatments like statins, bisphosphonates, and urate-lowering drugs by enabling efficacy and mechanistic evaluation prior to clinical trials.
List of Diseases and Research Models
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Disease Type
Animal Model / Study
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Obesity
•Model of high-fat diet-induced obesity
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Diabetes and Its Complications
•Model of STZ-induced types Ⅰ and Ⅱ diabetes
•Spontaneous type Ⅱ diabetes model
•Model of STZ plus unilateral nephrectomy-induced diabetic nephropathy
•Model of STZ plus high-fat diet-induced diabetic nephropathy
•Model of STZ plus incised wound-induced diabetic foot -
Hyperuricemia, Gout
•Model of adenine and hypoxanthine-induced hyperuricemia
•Model of dried yeast and adenine-induced hyperuricemia and gout
•Model of oteracil potassium plus ethambutol-induced chronic hyperuricemia
•Model of sodium oxalate diet-induced hyperuricemia -
Hyperlipidemia
•Spontaneous hyperlipidemia model
•Model of high-fat diet-induced hyperlipidemia -
Hepatopathy
•Model of western diet-induced plus spontaneous non-alcoholic steatohepatitis NASH model
•Model of complex factors (carbon tetrachloride plus 30% ethanol)-induced liver fibrosis
•Model of DMNA-induced liver fibrosis -
Anti-Glucocorticoid Side Effects
•Hormone metabolism disorders, withdrawal reactions and neuroendocrine suppression models
