Immune and Inflammatory Disease Models
Preclinical models of inflammation, pain, and immune responses are essential for evaluating anti-inflammatory and immunomodulatory therapies. Widely used in the development of TNF-α inhibitors (e.g., adalimumab) and IL-6/IL-17 blockers, these models help validate mechanisms of action and predict clinical efficacy in autoimmune and inflammatory diseases.
List of Diseases and Research Models
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Disease Type
Animal Model / Study
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Arthritis and Osteoarthritis
•Model of sodium urate-induced gouty arthritis
•Model of carrageenin-induced acute arthritis
•Model of BCG vaccine adjuvant-induced rheumatoid arthritis
•Model of type II collagen mixture-induced collagen arthritis
•Model of papain-induced degenerative osteoarthrosis
•Model of meniscus removal surgery-induced osteoarthrosis -
Dermatitis
•Solar dermatitis model
•Model of 2,4-dinitrobenzene-induced atopic dermatitis -
Vaginitis
•Model of gardnerella vaginalis-induced bacterial vaginitis
•Model of mixed bacterial infection-induced vaginitis -
Inflammation, Swelling, Immunosuppression
•Model of xylene-induced ear swelling
•Model of carrageenin-induced foot swelling
•Model of carrageenin-induced acute exudative inflammation (acute pleurisy)
•Model of glacial acetic acid-induced acute exudative inflammation (capillary permeability)
•Model of cotton ball granuloma-induced chronic proliferative inflammation
•Carbon expurgation test
•Serum hemolysin test
•Model of cyclosporin a-induced immunosuppression -
Autoimmune Disease
•Systemic lupus
•Erythematosus hypocellular models
