Ophthalmic Disease Models
HiLand provides robust in vivo models covering major front- and back-of-the-eye conditions. We support evaluation of therapeutic mechanisms, dose responses, and biomarker correlation across various ophthalmic indications. Our team ensures ethical compliance and validated, reproducible endpoints.
List of Diseases and Research Models
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Disease Type
Animal Model / Study
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Keratitis
•Fungal keratitis model
•Model of alkali burn-induced keratitis -
Conjunctivitis
•Bacterial conjunctivitis model
•Model of croton oil-induced irritant conjunctivitis
•Model of OVA-induced allergic conjunctivitis -
Xerophthalmia
•Model of scopolamine-induced dry eye with decreased tear film stability
•Model of hypertonic solution-induced dry eye with higher tear osmolarity
•Model of water-in-oil antigen-induced autoimmune dry eye
•Model of OVA-induced IgE-mediated immune dry eye
•Model of alkali burn-induced dry eye with decreased tear film stability
•Model of meibomian gland closed-induced dry eye with decreased tear film stability -
Glaucoma
•Model of compound carbomer-induced high intraocular pressure
•Model of polystyrene microsphere-induced high intraocular pressure -
Cataracts
•Model of sodium selenite-induced cataracts
•Senile cataract model -
Myopia
•Form-deprivation myopia model
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Retinopathy
•Model of Y79 tumor cells-induced retinoblastoma
•Wet macular degeneration (laser-induced CNV)
•Wet macular degeneration (VEGF injection-induced vascular leakage)
•dl-2-AAA-induced retinal NV
•Stz-induced type I diabetic retinopathy
Research Projects
Accomplished
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100
100 + preclinical studies on ophthalmic drugs including biological products, small molecule
drugs, eye drops, and pediatric ophthalmic drugs; -
60
60 clinical approvals for innovative ophthalmic drugs and generic drugs
